Phenotypic and functional characterization of adult brain neuropoiesis

Phenotypic and functional characterization of adult brain neuropoiesis.

The modern concept of neurogenesis in the adult brain is predicated on the premise that multipotent glial cells give rise to new neurons throughout life. Although extensive evidence exists indicating that this is the case, the transition from glial to neuronal phenotype remains poorly understood. A unique monolayer cell-culture system was developed to induce, expose, and recapitulate the entire...

Phenotypic and Functional Characterization

A study of cell surface phenotypes of PBL of myasthenia gravis (MG) patients showed that their T cells had a significantly higher percentage of 4B4+ T cells (the helper/inducer subset) than ageand sex-matched controls. The PBL of MG patients proliferated significantly higher than those of normal subjects (NS) in response to the purified a chain of the acetylcholine receptor (AChR). Anti-AChR an...

Functional and Phenotypic Characterization

Phenotypic and Functional Characterization

Phenotypic and Functional Characterization

Although the CD5 (T1) antigen was initially described as a pan-T cell membrane glycoprotein, we report that 14 of 40 normal individuals were found to have 5% or greater of their blood mononuclear cells characterized as CD3 (T3)+ but CDSby dual immunofluorescence flow cytometry. These cells expressed normal quantities of surface CD3 and CD2 but low levels of CD7, were CD8' and CD4-, and CD16-. I...